TABLE 1. Demographic and medical risk characteristics of patients with positive SARS-CoV-2 test results, by clinical setting and medications received — 41 health care systems in the National Patient-Centered Clinical Research Network, United States, March 2020–August 2021.
| Characteristic | No. (%)* |
||||
|---|---|---|---|---|---|
| All patients with positive SARS-CoV-2 test result | Patients receiving monoclonal antibodies | Inpatients with positive SARS-CoV-2 test result | Patients receiving dexamethasone | Patients receiving remdesivir | |
|
No. of unique patients
|
805,276 |
12,539 |
120,204 |
40,685 |
35,315 |
|
Demographics
| |||||
|
Age group, yrs
| |||||
| 20–39 |
312,680 (38.8) |
1,639 (13.1) |
20,966 (17.4) |
4,966 (12.2) |
3,354 (9.5) |
| 40–54 |
209,202 (26.0) |
2,933 (23.4) |
23,296 (19.4) |
8,285 (20.4) |
6,885 (19.5) |
| 55–64 |
128,550 (16.0) |
3,045 (24.3) |
24,025 (20.0) |
8,874 (21.8) |
7,779 (22.0) |
| 65–74 |
86,848 (10.8) |
3,075 (24.5) |
24,267 (20.2) |
9,124 (22.4) |
8,257 (23.4) |
| 75–84 |
47,047 (5.8) |
1,425 (11.4) |
18,016 (15.0) |
6,420 (15.8) |
6,056 (17.1) |
| ≥85 |
20,949 (2.6) |
422 (3.4) |
9,634 (8.0) |
3,016 (7.4) |
2,967 (8.4) |
|
Sex
| |||||
| Female |
437,651 (54.3) |
6,709 (53.5) |
59,583 (49.6) |
19,262 (47.3) |
16,607 (47.0) |
| Male |
367,359 (45.6) |
5,828 (46.5) |
60,603 (50.4) |
21,416 (52.6) |
18,704 (53.0) |
| Other†/Missing§ |
264 (0.0) |
3 (0.0) |
17 (0.0) |
8 (0.0) |
3 (0.0) |
|
Race
| |||||
| Asian |
22,968 (2.9) |
206 (1.6) |
4,396 (3.7) |
1,219 (3.0) |
1,003 (2.8) |
| Black or African American |
126,166 (15.7) |
1,904 (15.2) |
28,403 (23.6) |
8,879 (21.8) |
8,172 (23.1) |
| White |
493,181 (61.2) |
9,366 (74.7) |
59,212 (49.3) |
22,910 (56.3) |
19,318 (54.7) |
| Other¶ |
88,026 (10.9) |
773 (6.2) |
20,729 (17.2) |
6,151 (15.1) |
5,366 (15.2) |
| Missing§ |
74,935 (9.3) |
280 (2.2) |
7,449 (6.2) |
1,511 (3.7) |
1,443 (4.1) |
|
Ethnicity
| |||||
| Hispanic |
149,565 (18.6) |
1,006 (8.0) |
25,953 (21.6) |
7,557 (18.6) |
6,895 (19.5) |
| Non-Hispanic |
577,394 (71.7) |
11,189 (89.2) |
88,007 (73.2) |
31,627 (77.7) |
27,147 (76.9) |
| Other** |
5,553 (0.7) |
20 (0.2) |
273 (0.2) |
84 (0.2) |
104 (0.3) |
| Missing§ |
72,764 (9.0) |
318 (2.5) |
5,955 (5.0) |
1,410 (3.5) |
1,161 (3.3) |
|
Medical conditions associated with high risk††
| |||||
| Anemia |
72,830 (9.0) |
2,187 (17.4) |
33,072 (27.5) |
9,762 (24.0) |
8,553 (24.2) |
| Arrythmia |
73,318 (9.1) |
2,527 (20.2) |
39,255 (32.7) |
12,235 (30.1) |
10,828 (30.7) |
| Asthma |
60,080 (7.5) |
1,890 (15.1) |
16,045 (13.3) |
5,301 (13.0) |
4,944 (14.0) |
| COPD |
26,636 (3.3) |
879 (7.0) |
15,330 (12.8) |
5,551 (13.6) |
5,513 (15.6) |
| Cancer |
37,027 (4.6) |
1,641 (13.1) |
12,869 (10.7) |
4,716 (11.6) |
3,605 (10.2) |
| Chronic kidney disease |
50,580 (6.3) |
1,795 (14.3) |
30,206 (25.1) |
9,269 (22.8) |
8,418 (23.8) |
| Chronic pulmonary disorders |
100,625 (12.5) |
3,219 (25.7) |
32,617 (27.1) |
11,282 (27.7) |
10,582 (30.0) |
| Coagulopathy |
33,374 (4.1) |
985 (7.9) |
23,070 (19.2) |
7,442 (18.3) |
6,469 (18.3) |
| Congestive heart failure |
40,179 (5.0) |
1,344 (10.7) |
24,627 (20.5) |
7,868 (19.3) |
7,329 (20.8) |
| Coronary artery disease |
54,051 (6.7) |
2,074 (16.5) |
28,799 (24.0) |
9,305 (22.9) |
8,607 (24.4) |
| Diabetes type 2 |
107,527 (13.4) |
3,890 (31.0) |
47,963 (39.9) |
15,462 (38.0) |
14,706 (41.6) |
| Hypertension |
209,848 (26.1) |
7,265 (57.9) |
78,700 (65.5) |
25,653 (63.1) |
23,633 (66.9) |
| Mental health disorders |
97,046 (12.1) |
2,728 (21.8) |
26,443 (22.0) |
8,015 (19.7) |
7,044 (19.9) |
| Peripheral vascular disorders |
31,930 (4.0) |
1,250 (10.0) |
16,496 (13.7) |
5,373 (13.2) |
4,596 (13.0) |
| Severe obesity (BMI ≥40 kg/m2) |
60,052 (7.5) |
2,430 (19.4) |
20,271 (16.9) |
7,781 (19.1) |
6,891 (19.5) |
|
Outcome
§§
| |||||
| Critical care | 27,585 (3.4) | 225 (1.8) | 21,412 (17.8) | 10,675 (26.2) | 8,244 (23.3) |
Abbreviations: BMI = body mass index; CDM = common data model; COPD = chronic obstructive pulmonary disease; PCORnet = National Patient-Centered Clinical Research Network.
* Percentages are simple summary numbers (column percentages) out of the total in each category. Strata are not expected to sum to the total because the small cell masking by the data partners before submission of data.
† For sex stratifications, Other includes all remaining PCORnet CDM values that are not male or female.
§ For sex, race, and ethnicity stratifications, Missing includes PCORnet CDM values of Refuse to answer, No Information, Unknown, and missing values.
¶ For race stratifications, Other includes PCORnet CDM values of Native Hawaiian or Other Pacific Islander, American Indian or Alaska Native, Multiple races, and Other.
** For ethnicity stratifications, Other includes PCORnet CDM values of Other.
†† Recorded history of the diagnoses in electronic health record (outpatient or inpatient) within 3 years before a positive test. Patients can have more than one condition.
§§ Fourteen days before to 30 days after a positive test result.