Table 1.
Inhibitory function and targets of human clade B serpins.
| Serpin | Alternative Name | Inhibitory Function | Potential Protein Targets |
|---|---|---|---|
| SerpinB1 | PI-2, Neutrophil elastase inhibitor | + | Elastase, Chymotrypsin, Cathepsin G, Protease 3 |
| SerpinB2 | PAI-2 | + | uPA, tPA |
| SerpinB3 | SCCA1 | + | Papain, Cathepsin L, K, S |
| SerpinB4 | SCCA2, Leupin | + | Cathepsin G, Chymase |
| SerpinB5 | Maspin | − | - |
| SerpinB6 | CAP1, PI6 | + | Thrombin, Trypsin, Factor Xa, Cathepsin G, u-PA |
| SerpinB7 | Megsin | + | Plasmin |
| SerpinB8 | CAP2, PI8 | + | Furin, Trypsin, Factor Xa, Thrombin, Chymotrypsin, Subtilisin A |
| SerpinB9 | CAP3, PI9 | + | Granzyme B, Subtilisin A, Caspase 1, 4, 8, 10 |
| SerpinB10 | Bomapin, PI10 | + | Thrombin, Trypsin |
| SerpinB11 | Epipin | - | - |
| SerpinB12 | Yukopin | + | Trypsin, Plasmin |
| SerpinB13 | Headpin, Hurpin | + | Cathepsin K, L, V |
SCCA, Squamous cell carcinoma antigen; CAP, Cytoplasmic antiprotease; PI, Protease inhibitor; uPA, Urokinase plasminogen activator; tPA, Tissue plasminogen activator.