Table 1.
AR in different sub-types of breast cancer has different clinical outcomes.
| Types | AR Status (Cut-Off Used to Define AR + ve) | Case No. | Indicator of Clinical Outcomes 1 | Hazard Ratio (HR) | 95% Confidence Interval (CI) | p-Value | Reference |
|---|---|---|---|---|---|---|---|
| ER + ve | Positive (≥10% nuclear-stained) | 470 | DFS | 0.654 | 0.429–0.997 | 0.049 | [44] |
| Negative (<10% nuclear-stained) | 202 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 1024 | OS | 0.68 | 0.52–0.88 | - | [45] | |
| Negative (<1% nuclear-stained) | 140 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 2833 | BCM | 0.53 | 0.41 –0.69 | < 0.001 | [46] | |
| Negative (<1% nuclear-stained) | 470 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 609 | DSS | 0.259 | 0.139–0.482 | 0.000 | [47] | |
| Negative (<1% nuclear-stained) | 250 | 1 | - | - | |||
| High (mRNA Z-score) | 145 | DRFS | - | - | 0.008 | [48] | |
| Low (mRNA Z-score) | 144 | - | - | - | |||
| Positive (N/A) | - | DFS | 0.40 | 0.31–0.52 | < 0.001 | [54] | |
| Negative (N/A) | - | 1 | - | - | |||
| Positive (≥10% nuclear-stained) | 909 | OS | 0.71 | 0.53–0.95 | 0.022 | [55] | |
| Negative (<10% nuclear-stained) | 162 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 461 | DFS | 0.606 | 0.388–0.944 | 0.027 | [56] | |
| Negative (<1% nuclear-stained) | 337 | 1 | - | - | |||
| HER2 + ve/ ER-ve |
Positive (≥10% nuclear-stained) | 49 | OS | - | - | 0.074 | [44] |
| Negative (<10% nuclear-stained) | 42 | - | - | - | |||
| High (mRNA level) | 35 | DFS | 1.46 | 1.03–2.06 | 0.03 | [57] | |
| Low (mRNA level) | 49 | 1 | - | - | |||
| TNBC | Positive (≥1% nuclear-stained) | 78 | OS | 1.83 | 1.11–3.01 | 0.02 | [45] |
| Negative (<1% nuclear-stained) | 133 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 261 | OS | 2.159 | 1.224–3.808 | 0.008 | [58] | |
| Negative (<1% nuclear-stained) | 231 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 23 | DFS | 5.26 | 1.39–19.86 | 0.014 | [59] | |
| Negative (<1% nuclear-stained) | 38 | 1 | - | - | |||
| Positive (≥1% nuclear-stained) | 78 | DDFS | 1.82 | 1.10–3.02 | 0.020 | [60] | |
| Negative (<1% nuclear-stained) | 185 | 1 | - | - |
1 DFS: Disease free survival; OS: overall survival; BCM: breast cancer-specific mortality; DSS: disease-specific survival; DRFS: distant-relapse-free survival; DDFS: distant-disease-free survival.