Table 3.

Univariate and multivariate Cox regression analyses of prognostic factors, including the Cyld-Tak1 classes (overall survival).

	Univariate			Multivariate
Clinical Features	HR	std. Error	p -Value	HR	std. Error	p- Value
Age (≥60 vs. <60)	1.43	0.12	0.003	1.42	0.13	<0.01
Sex (male vs. female)	1.07	0.13	0.637
Alcohol abuse (true vs. false)	0.87	0.12	0.250
Hemochromatosis (tr. vs. f.)	0.70	0.27	0.186	0.69	0.28	0.183
HBV (pos. vs. neg.)	0.89	0.14	0.400
HCV (pos. vs. neg.)	1.07	0.14	0.608
BCLC (B-D vs. A)	1.83	0.16	<0.001	1.50	0.18	0.024
AFP Serum (> vs. ≤200 ng/mL)	2.00	0.13	<0.0001
Pathologic features
Grading (G3 vs. G1/G2)	1.50	0.13	0.003	1.30	0.14	0.073
VI (micro vs. none)	1.49	0.14	0.004	1.24	0.16	0.172
VI (macro vs. none)	3.20	0.15	<0.0001	2.74	0.16	<0.0001
Macrotrabecular Subtype	1.96	0.19	<0.001
intermed. comb. score (vs. low)	1.15	0.15	0.351	1.09	0.16	0.607
high comb. score (vs. low)	1.93	0.17	<0.0001	1.50	0.18	0.028