Figure 2.

Molecular effects exerted by lipopolysaccharides on odontoblasts. Figure summarizes results from studies conducted on hDPCs, regardless of LPS origin. In odontoblasts a main role in LPS stimulation is played by the TLR/MyD88/NF-κB pathway. This stimulation results in expression of IL-8, TNF-α and adhesion molecules. A variety of different pathways and particles activated in LPS-treated cells are presented both in deep blue brackets and by protein images with their names. Black arrows represent positive stimulation, dashed arrows show indirect activation, red ones—inhibition, green—translocation to another cell compartment. Created with BioRender.com 7 December 2020.