Table 1.
Groups | Body Weight (g) | |||||
---|---|---|---|---|---|---|
Stocked Day | Injection | Intragastric Administration | Behavioral Experiment | Dissection | Body Weight Gain | |
Normal | 27.4 ± 1.3 NS | 32.3 ± 1.3 NS | 33.4 ± 1.1 NS | 33.6 ± 1.6 NS | 33.8 ± 1.3 NS | 6.4 ± 0.6 NS |
Control | 27.6 ± 1.1 | 32.0 ± 0.3 | 33.4 ± 1.0 | 34.6 ± 1.6 | 34.2 ± 1.4 | 6.6 ± 0.5 |
CT50 | 27.1 ± 1.1 | 32.1 ± 0.9 | 33.0 ± 1.1 | 33.6 ± 1.5 | 33.0 ± 1.6 | 6.0 ± 1.2 |
CT100 | 27.5 ± 0.6 | 33.2 ± 1.1 | 33.9 ± 1.0 | 34.5 ± 1.7 | 33.5 ± 1.1 | 6.0 ± 1.1 |
CT200 | 27.6 ± 1.3 | 32.4 ± 1.4 | 33.7 ± 1.6 | 33.7 ± 1.7 | 33.5 ± 2.2 | 5.9 ± 1.4 |
DO | 26.8 ± 0.8 | 32.8 ± 0.8 | 32.8 ± 2.1 | 33.0 ± 1.2 | 32.3 ± 1.0 | 5.5 ± 1.1 |
Values are mean ± SD. NS: Non-significance. Normal: 0.9% NaCl + water; Control: Aβ25-35 + water; CT50: Aβ25-35 + CT (50 mg/kg/day); CT100: Aβ25-35 + CT (100 mg/kg/day); CT200: Aβ25-35 + CT (200 mg/kg/day); DO: Aβ25-35 + donepezil (5 mg/kg/day).