Figure 2.

Pedigrees of probands heterozygous for SCN5A mutations where at least one first-degree relative was available for screening. Circles indicate females, squares, males; symbols with diagonal lines represent deceased individuals. Open symbols represent asymptomatic individuals, filled symbols were affected by arrhythmogenic syndromes according to the color code. Parentship was not confirmed by genetic analyses in any case. SSS: sick sinus syndrome; PCCD: progressive cardiac conduction disease; VT: ventricular tachycardia; BrS: Brugada syndrome; LQTS: long QT syndrome; SCD: sudden cardiac death.