Table 1.

Definition, classification, histology, diagnosis, and treatment show differences between HIC/BPS and NHIC/BPS.

Item		HIC/BPS	NHIC/BPS
Definition		IC/BPS with Hunner lesions	IC/BPS without Hunner lesions
Classification		Hunner-type (Ulcerative) type	Non-Hunner-type (Unulcerative) type
Histopathology	Subepithelial chronic inflammation	Present	Absent or minimal
	Types of infiltrating inflammatory cells	Lymphocytes and plasma cells are dominant.	Plasma cells are few.
	Lymphoid follicles	Often present	Extremely rare
	Urothelium	Frequently denuded	Full layer is preserved
	Mast cell	Often present	Extremely rare
Diagnosis	Cystoscopy	Hunner lesions: presence	Hunner lesions: absence
	Bladder capacity	Low	Low
	Bladder biopsy	Dense inflammatory infiltration and epithelial denudation	Slight inflammation
Treatment	Fulguration/Distension	Fulguration/Distension	Distension
	Intravesical instillation	HA, chondroitin sulfate, Botulinum toxin, steroid	HA, chondroitin sulfate, Botulinum toxin, steroid
	Medicine	Necessary	Necessary