Table 1.
Experimental design for different colchicine niosomal emulgel formulations and their observed values of response.
| Formula | Independent Variables | Dependent Response | |||
|---|---|---|---|---|---|
| X1 (g) | X2 (g) | X3 (g) | R1 (cP) | R2 (%) | |
| F1 | 1 | 1 | 1 | 4772 ± 123 | 49.5 ± 4.0 |
| F2 | 1.5 | 1 | 0.8 | 5302 ± 188 | 42.8 ± 2.6 |
| F3 | 1.5 | 0.5 | 0.8 | 5645 ± 167 | 39.2 ± 3.9 |
| F4 | 1 | 0.5 | 1 | 4553 ± 219 | 50.8 ± 3.1 |
| F5 | 1.5 | 1 | 1.2 | 6952 ± 169 | 28.2 ± 1.2 |
| F6 | 1.5 | 0.75 | 1 | 6428 ± 179 | 29.4 ± 2.7 |
| F7 | 1.5 | 0.5 | 1.2 | 6655 ± 171 | 29.5 ± 3.5 |
| F8 | 1 | 0.75 | 0.8 | 4265 ± 184 | 55.1 ± 3.6 |
| F9 | 2 | 1 | 1 | 9592 ± 202 | 22.3 ± 2.5 |
| F10 | 1.5 | 0.75 | 1 | 5909 ± 246 | 33.6 ± 3.1 |
| F11 | 1.5 | 0.75 | 1 | 6125 ± 177 | 34.2 ± 3.8 |
| F12 | 2 | 0.75 | 1.2 | 9834 ± 210 | 21.5 ± 2.7 |
| F13 | 1.5 | 0.75 | 1 | 6396 ± 268 | 31.9 ± 2.9 |
| F14 | 2 | 0.5 | 1 | 8316 ± 176 | 25.2 ± 2.1 |
| F15 | 1 | 0.75 | 1.2 | 4991 ± 184 | 47.2 ± 3.4 |
| F16 | 2 | 0.75 | 0.8 | 7832 ± 219 | 26.1 ± 2.3 |
| F17 | 1.5 | 0.75 | 1 | 6290 ± 237 | 32.7 ± 3.4 |
X1: oil concentration; X2: surfactant concentration; X3: gelling agent concentration; R1 viscosity; R2: in vitro release.