Table 3.
Permeability parameters of clindamycin in hydrogel formulations.
| Formulation | Linear Regression Equation | Coefficient of Determination, R2 | Steady-State Flux, Jss [µg/cm2/h] |
Permeability Coefficient, Pm [cm/h × 103] |
Enhancement Factor (EF) |
|---|---|---|---|---|---|
| C1 | y = 43.64x + 6.2349 | 0.9874 | 43.64 | 3.862 | 1 |
| C2 | y = 117.86x + 69.187 | 0.9953 | 117.86 | 10.430 | 1 |
| G1 | y = 63.56x + 11.263 | 0.9774 | 63.56 | 5.625 | 1.46 * |
| G2 | y = 64.36x − 12.872 | 0.9903 | 64.36 | 5.695 | 1.47 * |
| G3 | y = 73.61x + 33.387 | 0.9914 | 73.61 | 6.514 | 1.69 * |
| G4 | y = 76.03x + 67.981 | 0.9810 | 76.03 | 6.728 | 1.74 * |
| G5 | y = 133.55x + 79.646 | 0.9878 | 133.55 | 11.819 | 1.13 ** |
| G6 | y = 135.16x + 85.278 | 0.9936 | 135.16 | 11.961 | 1.15 ** |
| G7 | y = 147.63x + 56.718 | 0.9940 | 147.63 | 13.065 | 1.25 ** |
| G8 | y = 159.29x + 74.819 | 0.9942 | 159.29 | 14.096 | 1.35 ** |
* vs. C1; ** vs. C2.