Fig. 5.

The CatSper channel is functional but at a significantly reduced capacity in C2cd6^−/− cauda sperm. (A) Representative CatSper currents in cauda sperm from adult C2cd6^+/− and C2cd6^−/− mice. (B) CatSper currents in C2cd6^+/− cauda sperm before (control) and after alkalization with 10 mM NH₄Cl. (C) CatSper currents in C2cd6^−/− cauda sperm before (control) and after alkalization with 10 mM NH₄Cl. (D) Average CatSper currents in cauda sperm measured at −80 mV and +80 mV. The experiments were performed on cauda sperm from four C2cd6^+/− and four C2cd6^−/− mice at 3-6 months of age. *P<0.05, **P<0.01 (paired Student's t-test). n=4.