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Schematic diagram of coupled versus uncoupled endothelial nitric oxide synthase or eNOS showing that uncoupled eNOS can generate a highly toxic super radical as shown by the abbreviation O2-, the ion superoxide. Other abbreviations: O2 - Oxygen; NADPH - Nicotinamide adenine dinucleotide phosphate hydroxide; NADP+ - Nicotinamide adenine dinucleotide phosphate; FAD - Flavin adenine dinucleotide; FMN - Flavin mononucleotide; CaM - Calmodulin.
