Table 4.
Uni- and multivariate association of risk factors with overall survival by Cox regression.
| Variable | Univariate Model | Multivariate Model | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age, per 10 years | 1.281 (1.060–1.549) | 0.010 | 1.038 (1.013–1.064) | 0.003 |
| Sex: female vs. male | 0.997 (0.624–1.592) | 0.990 | - | - |
| Performance status: 1 vs. 0 | 2.679 (1.624–4.419) | <0.001 | 2.457 (1.305–4.624) | 0.005 |
| Child Pug: B vs. A | 2.284 (1.362–3.833) | 0.002 | 2.398 (1.128–5.097) | 0.023 |
| MELD score, per unit | 1.090 (1.016–1.169) | 0.016 | 1.117 (1.007–1.239) | 0.036 |
| ALBI score, per unit | 1.573 (1.077–2.296) | 0.019 | 0.808 (0.452–1.444) | 0.471 |
| log10αFP, per unit | 1.343 (1.101–1.638) | 0.004 | 1.367 (1.024–1.825) | 0.034 |
| Multinodular tumor vs. single tumor | 1.729 (1.146–2.608) | 0.009 | 1.253 (0.697–2.250) | 0.451 |
| Maximum nodule size, per unit | 1.002 (0.997–1.008) | 0.410 | - | - |
| BCLC B–C vs. 0–A | 1.329 (0.904–1.952) | 0.148 | - | - |
| Tumor grading 3 vs. 1–2 | 2.151 (1.471–3.146) | <0.001 | 1.265 (0.748–2.141) | 0.381 |
| Microvascular invasion yes vs. no | 2.388 (1.633–3.491) | <0.001 | 2.130 (1.281–3.540) | 0.004 |
| Satellitosis yes vs. no | 2.690 (1.758–4.144) | <0.001 | 1.835 (1.064–3.166) | 0.029 |
| Capsule infiltration yes vs. no | 1.396 (0.916–2.128) | 0.121 | - | - |
| R1 resection vs. R0 resection | 2.636 (1.574–4.414) | <0.001 | 3.540 (1.866–6.718) | <0.001 |
| LI-RADS 5 vs LI-RADS 3–4 | 1.009 (0.662–1.536) | 0.968 | 0.862 (0.493–1.506) | 0.602 |
Abbreviations: MELD, Model for End Stage Liver Disease; ALBI, Albumin-Bilirubin; αFP, alpha-fetoprotein; BCLC, Barcelona Clinic for Liver Cancer; LI-RADS, Liver Imaging Reporting and Data System.