Table 5.
Univariate and multivariate association of risk factors with cancer-specific death by Cox cause-specific regression considering death by other causes as a competing risk.
| Variable | Univariate Model | Multivariate Model | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age, per 10 years | 1.074 (0.842–1.370) | 0.564 | 1.032 (0.997–1.068) | 0.071 |
| Sex: female vs. male | 0.879 (0.443–1.745) | 0.713 | - | - |
| Performance status: 1 vs. 0 | 2.431 (1.186–4.981) | 0.015 | 1.803 (0.728–4.464) | 0.203 |
| Child Pug: B vs. A | 3.054 (1.589–5.867) | 0.001 | 2.072 (0.733–5.860) | 0.170 |
| MELD score, per unit | 1.160 (1.061–1.269) | 0.001 | 1.192 (1.037–1.369) | 0.013 |
| ALBI score, per unit | 2.262 (1.350–3.791) | 0.002 | 1.005 (0.437–2.313) | 0.991 |
| log10αFP, per unit | 1.597 (1.235–2.065) | <0.001 | 1.707 (1.138–2.559) | 0.010 |
| Multinodular tumor vs. single tumor | 2.261 (1.302–3.925) | 0.004 | 1.144 (0.521–2.514) | 0.737 |
| Maximum nodule size, per unit | 1.003 (0.995–1.011) | 0.442 | - | - |
| BCLC B–C vs. 0–A | 1.508 (0.882–2.577) | 0.133 | - | - |
| Tumor grading 3 vs. 1–2 | 2.853 (1.671–4.871) | <0.001 | 1.844 (0.870–3.907) | 0.110 |
| Microvascular invasion yes vs. no | 2.901 (1.703–4.941) | <0.001 | 1.948 (0.938–4.049) | 0.074 |
| Satellitosis yes vs. no | 4.097 (2.365–7.098) | <0.001 | 2.388 (1.188–4.802) | 0.015 |
| Capsule infiltration yes vs. no | 1.073 (0.576–2.000) | 0.823 | - | - |
| R1 resection vs. R0 resection | 3.477 (1.775–6.811) | <0.001 | 3.463 (1.453–8.252) | 0.005 |
| LI-RADS 5 vs LI-RADS 3–4 | 1.361 (0.718–2.582) | 0.345 | 0.829 (0.383–1.795) | 0.634 |
Abbreviations: MELD, Model for End Stage Liver Disease; ALBI, Albumin-Bilirubin; αFP, alpha-fetoprotein; BCLC, Barcelona Clinic for Liver Cancer; LI-RADS, Liver Imaging Reporting and Data System.