Table 3. Histopathology lung features in decedent66ts hospitalized with respiratory illness with (COVID+) and without (COVID-) SARS-CoV-2 infection.
| COVID+ | COVID- | |
|---|---|---|
| n = 75 | n = 42 | |
| Necrotizing granulomata | 5 (7) | 7 (17) |
| Non-necrotizing granulomas | 0 (0) | 1 (2) |
| Fungi | 0 (0) | 1 (2) |
| Aspirated material | 1 (1) | 1 (2) |
| Neutrophilic infiltrate | 20 (28) | 13 (31) |
| Intra-alveolar hemosiderosis | 12 (17) | 10 (24) |
| Congestion of alveolar septa | 66 (92) | 37 (88) |
| Alveolar septal oedema | 60 (83) | 28 (67) |
| Interstitial inflammation | 67 (93) | 38 (90) |
| Intravascular fibrin/microthrombi | 25 (35) | 12 (29) |
| Megakaryocytes | 43 (60) | 23 (55) |
| Intra-alveolar hemorrhage | 15 (21) | 5 (12) |
| Intra-alveolar oedema | 16 (22) | 5 (12) |
| Intra-alveolar fibrin | 33 (46) | 16 (38) |
| Hyaline membranes | 46 (64) | 12 (29) |
| Alveolar collapse | 48 (67) | 23 (55) |
| Type II pneumocyte overall | 61 (85) | 26 (62) |
| Type II pneumocyte morphology-Cytomegaly | 55 (76) | 19 (45) |
| Type II pneumocyte morphology-Nucleomegaly | 53 (74) | 19 (45) |
| Type II pneumocyte morphology-Multinucleation | 45 (63) | 16 (38) |
| Type II pneumocyte proliferation-Syncytia formation | 24 (33) | 1 (2) |
| Increased alveolar macrophages | 63 (88) | 37 (88) |
| Alveolar septal necrosis | 61 (85) | 35 (83) |
| Intra-alveolar or Septal collagen or honeycombing | 60 (83) | 39 (93) |
| Intra-alveolar organization/organizing pneumonia | 22 (31) | 4 (10) |
| Septal collagen deposition | 57 (79) | 37 (88) |
| Honeycombing/microcystic fibrosis | 7 (10) | 3 (7) |
Results are n (%).