Table A1.

Genes contributing to polygenic risk of the ischemic stroke.

Stroke Subtype	Candidate Gene	Chromosome	Polymorphisms	Reference
Large artery stroke	HDAC9	7p21.1	rs2107595; rs11984041	PMID: 26708676
	CDKN2A/CDKN2B	9p21.3	rs23832073	PMID: 22306652
	EDNRA	4q31	rs17612742	PMID: 30356112
	TM4SF4-TM4Sn	3q25	rs7610618	PMID: 32874429
	LINC01492	9q31	rs10990643	PMID: 31306060
Cardioembolic stroke	PITX2	4q25	rs2200733; rs10033464; rs2723334	PMID: 18991354 PMID: 26935894
	ZFHX3	16q22.3	rs7193343-T; rs12932445	PMID: 19597491 PMID: 26935894
	ZNF566	19q13.12	N/A
	PDZK1IP1	1p33	N/A
	RGS7	1q43	rs146390073	PMID: 32874429
	NKX2-5	5q35	rs6891174	PMID: 32874429
Other and multiple types of strokes	HABP2	10q25.3	rs41292628	PMID: 30070759
	ADCY2	5p15	rs35510613	PMID: 30070759
	ANK2	4q25	rs34311906	PMID: 32874429
	FGA	4q31	rs6825454	PMID: 32874429
	LOC100505841	5q23	rs2303655	PMID: 33293549
	CDK6	7q21	rs42039	PMID: 32874429
	PDE3A	12p12	rs7304841	PMID: 32874429
	FURIN-FES	15q26	rs4932370	PMID: 32874429
	PRPF8	17p13	rs11867415	PMID: 32874429
	ILF3-SLC44A2	19p13	rs2229383	PMID: 32874429
	ABO	9q34	rs505922	PMID: 23381943
	MMP12	11q22	rs660599	PMID: 25078452
	SH2B3	12q24	rs3184504	PMID: 32874429
All types of strokes (ischemic and hemorrhagic)	CASZ1	1p36	rs880315	PMID: 32874429
	WNT2B	1p13	rs12037987	PMID: 32874429
	KCNK3	2p23	rs12476527	PMID: 32874429
	SLC22A7-ZNF318	6p21	rs16896398	PMID: 29531354
	chr9p21	9p21	rs7859727	PMID: 32874429
	SH3PXD2A	10q24	rs4630220	PMID: 33293549
	TBX3	12q24	rs35436	PMID: 32874429
	LRCH1	13q14	rs9526212	PMID: 32874429
	SMARCA4-LDLR	19p13	rs8103309	PMID: 32874429
	PMF1-SEMA4A	1q22	rs1052053	PMID: 32874429
	FOXF2	6p25	rs12204590	PMID: 27068588
	ZCCHC14	16q24.2	rs12445022	PMID: 27997041