Table 2.
Significant results from the GWAS gene-based association studies on the OMIM gene list (autosomal).
| Gene Symbol | Mendelian Disorder | ADHD Phenotype in Mendelian Disorder | Comorbid Psychiatric Phenotypes in Mendelian Disorder | ADHD Gene-Based p-Value |
Adjusted p-Value * |
Significant Gene-Based Association of Comorbidities |
|---|---|---|---|---|---|---|
| MANBA | #248510 | Hyperactivity | Aggression | 5.99 × 10−8 | 6.65 × 10−6 | |
| UQCC2 | #615824 | Hyperactivity | ASD/Aggression | 5.88 × 10−4 | 0.0326 | |
| HIVEP2 | #616977 | Hyperactivity/impulsivity | ASD/Anxiety | 1.10 × 10−3 | 0.0407 | ASD/Anxiety |
| FOXP1 | #613670 | Hyperactivity | ASD/Aggression/OCD | 2.43 × 10−3 | 0.0674 | ASD/Aggression |
| KANSL1 | #610443 | Hyperactivity/impulsivity | ASD/Anxiety | 3.56 × 10−3 | 0.0790 | ASD |
| AUH | #250950 | Short attention span | - | 4.63 × 10−3 | 0.0857 |
ADHD: Attention deficit/hyperactivity disorder; ASD: Autism spectrum disorders. OCD: Obsessive-compulsive disorder. In bold, overcoming Bonferroni correction. * p-value adjusted by False Discovery Rate (FDR).