Table 1.
Forty-seven independent SNPs associated with dental caries and periodontitis.
| No | Gene | SNP | EA: EAF | β (SE) | p-Value |
|---|---|---|---|---|---|
| 1 | AMY1C | rs72694438 | a:0.21 | 0.021(0.0033) | 2.25 × 10−10 |
| 2 | KRTCAP2 | rs4971099 | a:0.55 | −0.021(0.0027) | 7.47 × 10−15 |
| 3 | SYT14 | rs2046850 | t:0.19 | −0.019(0.0033) | 1.77 × 10−8 |
| 4 | ITPKB | rs3820640 | t:0.84 | 0.020(0.0037) | 2.65 × 10−8 |
| 5 | KCNJ3 | rs2652452 | a:0.45 | −0.016(0.0027) | 3.27 × 10−9 |
| 6 | ZNF804A | rs263771 | a:0.23 | 0.018(0.0031) | 6.53 × 10−9 |
| 7 | WNT10A | rs121908120 | a:0.03 | −0.081(0.0083) | 2.03 × 10−22 |
| 8 | ADCY3 | rs11676272 | a:0.52 | −0.015(0.0026) | 1.07 × 10−8 |
| 9 | ALK | rs80270335 | t:0.09 | 0.027(0.0045) | 2.1 × 10−9 |
| 10 | FAM150B | rs62106258 | t:0.95 | 0.042(0.0062) | 8.6 × 10−12 |
| 11 | AAK1 | rs5831974 | d:0.45 | −0.016(0.0027) | 6.97 × 10−10 |
| 12 | STAG1 | rs61790808 | a:0.64 | −0.016(0.0028) | 9.1 × 10−9 |
| 13 | KCNH8 | rs9831002 | t:0.49 | −0.016(0.0026) | 8.79 × 10−10 |
| 14 | OPA1 | rs185566659 | a:0.032 | 0.045(0.0075) | 1.54 × 10−9 |
| 15 | RARB | rs7429279 | a:0.41 | 0.016(0.0027) | 1.28 × 10−9 |
| 16 | RBM5 | 3:50135699DI | d:0.48 | −0.018(0.0027) | 4.79 × 10−12 |
| 17 | EFNA5 | rs1352724 | a:0.22 | −0.018(0.0032) | 3.64 × 10−8 |
| 18 | C5orf66 | rs1122171 | t:0.59 | 0.044(0.0027) | 2.84 × 10−62 |
| 19 | CDH9 | rs55769264 | a:0.45 | 0.015(0.0027) | 2.84 × 10−8 |
| 20 | FGF10 | rs1482698 | c:0.38 | 0.020(0.0027) | 1.47 × 10−13 |
| 21 | HLA | rs9366651 | t:0.51 | −0.029(0.0026) | 2.66 × 10−28 |
| 22 | LOC157273 | rs898797 | t:0.59 | 0.015(0.0027) | 1.52 × 10−8 |
| 23 | PBX3 | rs10987008 | a:0.64 | 0.021(0.0028) | 7.47 × 10−14 |
| 24 | DMRTA1 | rs10811723 | a:0.30 | −0.019(0.0029) | 3.41 × 10−11 |
| 25 | PRUNE2 | rs7852129 | a:0.89 | −0.025(0.0038) | 7.91 × 10−11 |
| 26 | STFA1P | rs7918807 | t:0.52 | 0.015(0.0027) | 3.58 × 10−8 |
| 27 | P2RY2 | rs149467613 | a:0.05 | −0.034(0.0062) | 3.21 × 10−8 |
| 28 | KLRAP1 | rs10772314 | a:0.40 | −0.015(0.0027) | 3.16 × 10−8 |
| 29 | CA12 | rs72748935 | t:0.46 | −0.028(0.0027) | 1.31 × 10−26 |
| 30 | NEO1 | rs6495046 | c:0.36 | −0.017(0.0028) | 3.47 × 10−10 |
| 31 | CHRNA3 | rs10851907 | a:0.41 | 0.016(0.0027) | 1.03 × 10−9 |
| 32 | RHCG | rs2072693 | t:0.48 | 0.014(0.0026) | 4.92 × 10−8 |
| 33 | TMEM219 | rs8054556 | a:0.46 | 0.016(0.0027) | 2.23 × 10−9 |
| 34 | SALL1 | rs1108343 | t:0.36 | 0.016(0.0028) | 1.32 × 10−8 |
| 35 | FOXL1 | rs10048146 | a:0.81 | −0.026(0.0034) | 5.2 × 10−14 |
| 36 | NPEPPS | rs3865314 | a:0.51 | 0.015(0.0026) | 1.48 × 10−8 |
| 37 | HOXB-AS2 | rs9905793 | a:0.091 | 0.027(0.0046) | 6.51 × 10−9 |
| 38 | KCNJ2 | rs34559440 | t:0.68 | −0.016(0.0028) | 1.14 × 10−8 |
| 39 | LOC100499467 | rs7217268 | a:0.38 | 0.016(0.0027) | 1.48 × 10−9 |
| 40 | BAHCC1 | rs57067187 | t:0.63 | 0.015(0.0027) | 6.9 × 10−9 |
| 41 | MC4R | rs28822480 | a:0.29 | 0.021(0.0029) | 7.08 × 10−13 |
| 42 | CRLF1 | rs2238651 | t:0.24 | 0.017(0.0031) | 4.39 × 10−8 |
| 43 | MAMSTR | rs11672900 | a:0.47 | −0.020(0.0027) | 4.67 × 10−14 |
| 44 | HAO1 | rs4816017 | a:0.29 | −0.017(0.0029) | 7.08 × 10−9 |
| 45 | MTMR3 | rs140357883 | d:0.84 | 0.022(0.0036) | 2.33 × 10−9 |
| 46 | FAM118A | rs1569414 | t:0.73 | −0.020(0.0030) | 1.19 × 10−11 |
| 47 | HDX | rs5922945 | t:0.34 | −0.016(0.0028) | 1.55 × 10−8 |