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Expression of β-galactosidase (LacZ) in P0 mice. H&E staining shows no abnormalities in Bmp3−/− mice (C) compared to WT (A) mice. X-gal staining shows no LacZ reporter protein in WT (B), while in Bmp3−/− mice (D) localization of LacZ reporter protein can be observed in bone (yellow arrows), hair follicles (red arrows), and lungs (green arrow). X-gal staining was particularly pronounced in the viscerocranium and the base of the skull.
