Skip to main content
. 2022 Jan 6;23(2):592. doi: 10.3390/ijms23020592

Figure 5.

Figure 5

Long-term synaptic plasticity in the DMSXL hippocampus. (A) Effects of the inhibitor of glutamate transporter DL-TBOA on fEPSPs. DL-TBOA, applied for 10 min at 40 µM, induced a strong depression of the synaptic transmission in DG of both DMSXL (n = 4 mice, n = 8 slices) and WT mice (n = 5 mice; n = 9 slices). The effect was significantly stronger in DMSXL mice, ** p = 0.002. Right, sample traces of recordings before (black) and 20 min after TBOA application (grey) are shown. (B) LTP in CA1. The time course of LTP following a 3 × 100 Hz stimulation was significantly decreased in hippocampal slices from DMSXL mice (n = 9 mice; n = 19 slices) as compared with WT controls (n = 9 mice; n = 19 slices), * p = 0.022. The potentiation measured 60 min after stimulation was not different between genotypes, p = 0.1. Examples of fEPSP recordings during the baseline (a) and 60 min after induction of LTP (b) are shown on the right. (C) LTP in DG. LTP induced by a 2 × 100 Hz stimulus was significantly decreased in DMSXL mice (n = 7 mice; n = 12 slices) during the early phase postinduction (first 15 min following stimulation) compared with WT (n = 6 mice; n = 15 slices). *p = 0.019. The mean LTP magnitude during the last 15 min of the recordings was comparable between genotypes, p = 0.17. The overall time course of LTP was significantly different in DMSXL mice, *p = 0.047. On the right, individual traces of fEPSPs are shown in the three conditions: before (a), 10 min after stimulation (b), and 60 min after stimulation (c).