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The possible molecular regulation mechanism between HIF-1 and circadian clock proteins. (a) HIF-1 can bind to HRE in promotors of circadian clock genes such as Per1, Cry1, and CLOCK. (b) Transcriptional activity of BMAL1:CLOCK leads to increased HIF-1 expression. (c) CRY1 and PER1 increase HIF-1 affinity to HRE, enhancing HIF-1 activity. (d) Influence of hypoxia-dependent acidification on circadian clock genes expression.
