Table 1.
A comparison between PACAP and commonly used DED drugs.
| Medications | Water Supplementation. Retention | Anti-inflammation | Suppretion of Injury | Mucin Secretion | Tear Secretion | Product Names |
|---|---|---|---|---|---|---|
| Artificial tears | + [22] | - | - | - | - | Many products |
| Hyaluronic acid | + [90] | - | + [29] | - | - | Hyalein® |
| Loteprednol Etabonate | - | + [33] | - | - | - | Lotemax® Loterex® |
| Cyclosporin A | - | + [39] | + [40] | - | + [38] | Restasis® |
| Rebamipide | - | - | - | + [47,48] | + [50] | Mucista® |
| Diquafosol | - | + [55] | + [55] | + [55,63] | + [55] | Diquas® |
| Lifitegrast | - | + [61,62] | - | - | - | Xiidra® |
| PACAP | - | + [*] | + [*] | ? | + [*] |
+: Reported [ref], * Unpublished results, manuscript in preparation. -: Not reported. ?: Unknown.