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. 2022 Jan 20;17(1):e0262832. doi: 10.1371/journal.pone.0262832

Fig 3. Nkx2.1cre+Tpl2fl/- mice have impaired early viral control but normal inflammatory cytokine profiles.

Fig 3

(A) Lung viral titers determined by plaque assay in mice infected with 104 pfu influenza A/x31 for the indicated times. Pooled data from 4 separate experiments, 1 experiment per time point. Mice per group- D1: Tpl2fl/-, N = 10. Nkx2.1cre+Tpl2fl/-, N = 8; D3: Tpl2fl/-, N = 7. Nkx2.1cre+Tpl2fl/-, N = 6; D5: Tpl2fl/-, N = 3, Nkx2.1cre+Tpl2fl/-, N = 7; D7: Tpl2fl/-, N = 10, Nkx2.1cre+Tpl2fl/-, N = 9. (B) Cytokine expression in mice treated as in A was determined by Procartaplex immunoassay; data representative of 2 experiments. Mice per group—UI Tpl2fl/-, N = 4, Nkx2.1cre+Tpl2fl/-, N = 4; D1: Tpl2fl/-, N = 3, Nkx2.1cre+Tpl2fl/-, N = 3; D3: Tpl2fl/-, N = 6, Nkx2.1cre+Tpl2fl/-, N = 6; D5 Tpl2fl/-, N = 3, Nkx2.1cre+Tpl2fl/-, N = 3; D8.5: Tpl2fl/-, N = 4, Nkx2.1cre+Tpl2fl/-, N = 5; Error bars represent means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; one-way ANOVA unless otherwise noted.