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A schematic diagram of the nitrate–nitrite–nitric oxide (NO3−–NO2−–NO) pathway, which is facilitated by environments of low oxygen tension and acidosis. The conversion of NO2− to NO occurs via various enzymatic reactions; S-nitrosothiols (RSNO) can decompose to form NO. XOR = xanthine oxidoreductase; deoxy-Hb = deoxyhemoglobin; deoxy-Mb = deoxymyoglobin.
