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. 2022 Jan 11;23(2):752. doi: 10.3390/ijms23020752

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Number of publications on epigenetics and pain from 2008 to 2020. Number of results returned from a search on PubMed (https://pubmed.ncbi.nlm.nih.gov/; access date 15 June 2021) for: (A) pain + epigenetic; and (B) pain + DNA methylation/histone PTM/ ncRNA. Black: all research papers; grey: review articles; magenta: original research articles; dash-dot patter: clinical trials; dashed line: ncRNAs; dotted line: DNA methylation; blue: histone PTMs. Graphs were generated using software GraphPad Prism Version 7.03.