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. 2022 Jan 7;23(2):646. doi: 10.3390/ijms23020646

Figure 2.

Figure 2

(A): Schematic of transgenic mouse model for conditional overexpression of AZGP1 in the proximal tubule. (B): tdTomato positive tubules showing Ai14 reporter expression of successful Cre recombination after tamoxifen administration. (C): AZGP1 mRNA expression levels in control and UUO kidneys at 2 weeks after tamoxifen treatment. (D): AZGP1 serum levels of AZGP1 overexpressing mice as measured by ELISA. (E): LTL staining and Picrosirius Red staining after 14 days of UUO. (F): Quantification of LTL staining (G): Quantification of Picrosirius Red. (H–J): Damage and fibrosis marker mRNA expression after 14 days UUO. Significance was tested by student’s t-test. * p < 0.05; ** p < 0.01; *** p < 0.001.