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. 2022 Jan 14;23(2):869. doi: 10.3390/ijms23020869

Figure 5.

Figure 5

Schematic summary of TX-100 and SL-11W detergent interactions with DOCP SLB platform and proposed morphological changes based on QCM-D data. The DOPC phospholipid and TX-100 and SL-11W detergent molecules are represented by gray, orange, and magenta headgroup colors, respectively. Illustrative steps are shown for (A) TX-100 that induces rapid membrane solubilization starting from compound addition and resulting in complete lipid bilayer removal, and (B) SL-11W that induces membrane budding upon compound addition but does not cause membrane solubilization as indicated by final QCM-D measurement responses post-washing. Note that the spherical structures in AI and BI are intended to represent TX-100 and SL-11W detergent micelles, respectively, while the spherical structures in AII are intended to represent mixed micelles that form during membrane solubilization. In BII, membrane budding is driven by the intercalation of SL-11W molecules into the lipid bilayer, which causes local changes in spontaneous curvature.