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. 2022 Jan 13;23(2):851. doi: 10.3390/ijms23020851

Figure 2.

Figure 2

mtHsp22 overexpression rescues spatial reversal learning and memory in rTg4510 mice. (a) The 2-day Radial-Arm Water Maze task with reversal was used to assess spatial memory in non-transgenic (Non-Tg) and rTg4510 mice injected with GFP (n = 10/Non-Tg; n = 10/rTg4510), wtHsp22 (n = 11/Non-Tg; n = 10/rTg4510), or mtHsp22 (n = 10/Non-Tg; n = 10/rTg4510). Mice were tested in 12 trials per day for training (Day 1), testing (Day 2), and reversal (Day 3), and the number of errors was recorded. Average errors over each set of three trials is shown (mean ± SEM, ** p < 0.01). Non-Tg and rTg4510 mice injected with GFP (n = 10/Non-Tg; n = 10/rTg4510), wtHsp22 (n = 11/Non-Tg; n = 10/rTg4510), or mtHsp22 (n = 10/Non-Tg; n = 10/rTg451)0 were also evaluated in an open field for (b) total distance traveled in meters (m) and (c) time spent in the center in seconds (s) over the course of 10 min (mean ± SEM), ** p < 0.0027.