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. 2022 Jan 13;23(2):851. doi: 10.3390/ijms23020851

Figure 3.

Figure 3

Hsp22 overexpression increases synaptic plasticity in rTg4510 mice. After recording a 20-min baseline, long-term potentiation (LTP) was induced in the Schaffer collaterals with high-frequency stimulation (HFS) (5 bursts of 200 Hz separated by 200 ms, repeated 6 times with an intertrain interval of 10 s). fEPSP was recorded for 60 min in (a) rTg4510, and (b) non-transgenic (Non-Tg) mice injected with GFP (n = 4/Non-Tg; n = 4/rTg4510), wtHsp22 (n = 4/Non-Tg; n = 4/rTg4510), or mtHsp22 (n = 4/Non-Tg; n = 4/rTg4510) (mean ± SEM, * p < 0.05, **** p < 0.0001). Representative traces are shown: 1 (teal) indicates baseline, 2 (pink) indicates early LTP potentiation in the first 3 min following HFS, and 3 (blue) indicates late LTP in the last 3 min of recording. The input/output curves of the fEPSP slope (mV/ms) versus the fiber volley amplitude (mV) in (c) rTg4510 and (d) Non-Tg mice injected with GFP, wtHsp22, or mtHsp22 (mean ± SEM).