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Overexpression of wtHsp22 and mtHsp22 does not alter tau accumulation. Immunohistochemical staining and quantification of the hippocampi of rTg4510 mice injected with GFP (n = 6), wtHsp22 (n = 6), or mtHsp22 (n = 6) for (a,b) total tau; (c,d) pS262 tau; (e,f) pT231 tau; (g,h) Gallyas silver, and (i,j) T22 oligomeric tau (mean ± SEM; scale bar represents 200 µm; inset represents 10 µm).
