AD: |
Alzheimer’s disease |
WT: |
wild type mouse expressing murine 4Rtau |
mtWT: |
homozygous transgenic mouse knock-out for murine tau protein |
hTau: |
homozygous transgenic mouse knock-out for murine tau protein and heterozygous expressing human forms of 3Rtau and 4Rtau proteins |
3Rtau: |
tau with three repeats |
4Rtau: |
tau with four repeats |
β-actin; CK1-δ |
casein kinase δ |
eIF2α |
eukaryotic initiation factor 2α |
GSK β: |
glycogen synthase kinase 3β |
IRE1: |
inositol-requiring enzyme 1α |
LAMP1: |
lysosomal-associated membrane protein 3 |
LC3: |
microtubule-associated protein 1A/1B-light chain 3 |
MAP2: |
microtubule-associated protein 2 |
NFL: |
neurofilament light molecular weight |
p38: |
p38-kinase |
PHF1: |
anti-paired helical filament 1 |
PKAα/β: |
cAMP-dependent protein kinase A |
SAPK/JNK: |
stress-activated protein kinase/Jun amino-terminal kinase |
SRC: |
tyrosine-protein kinase SRC |
Tau 5: |
monoclonal recognizing total tau protein |
Tau AT8 |
monoclonal tau antibody phosphorylation sites Ser202/Thr305 |
Tau C3: |
tau truncated at aspartic acid 421 |
Tau MC1: |
conformation tau |
Tau-N: |
nitrated tau |
Tau-P: |
phosphorylated tau. The phosphorylation or nitration of the protein at the specific site is indicated in every case |