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General scheme for the synthesis of the peptidomimetics 1–8, in the case of compound 9 (structure shown in Table 2 instead of tyrosine in the first position, 2,6-dimethyltyrosine (Dmt) is used in the synthesis: (a) Boc-AA, DIC, HOBt, (b) trifluoroacetic acid (TFA), (c) N,N-diisopropylethylamine (DIPEA), (d) steps a–c, (e) piperidine, (f) DIC, HOBt, (g) protected linker: Boc-d-Ala or Boc-β-Ala or Fmoc-Ahx or Fmoc-4-AMB or Fmoc-4-APhAc or Boc-Gly, Boc-Pro, (h) HF.
