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Dose-dependent antinociception of SI 1/28 following i.p. administration in the mouse formalin assay. Control mice were treated with saline (0.9%), morphine or the parent S1R antagonist, SI 1/13. All points represent summed time spent licking ± SEM of 7–13 mice. Note that SI 1/13 data is as previously published in reference [22].
