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. 2022 Jan 6;23(2):615. doi: 10.3390/ijms23020615

Figure 3.

Figure 3

Dose- and time-dependent anti-allodynic activity of SI 1/28 (squares) in the mouse CCI assay of neuropathic pain. Mechanical allodynia produced from sciatic nerve ligation was reduced from 40–80 min (10 mg/kg, i.p., red squares) and 60–80 min (45 mg/kg, i.p.; purple squares), similar to the effect of the positive control, gabapentin (green hexagon). SI 1/28 (45 mg/kg, i.p.; purple squares) was significantly increased compared to the parent compound, SI 1/13 (pink diamonds). n = 8–17 for all groups. * = significantly different from vehicle controls; # = significantly different from SI 1/13; p < 0.05; two-way RM ANOVA.