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Dose- and time-dependent (a) spontaneous ambulation and (b) respiratory effects of morphine (30 mg/kg, i.p.; red circles) or SI 1/28 (60 mg/kg, i.p.; pink squares) evaluated in the CLAMS/Oxymax system with C57BL6/J mice. * = significantly greater than vehicle effect (gray dashed line), p < 0.05; two-way ANOVA w/Dunnett’s post hoc test. n = 12 mice/group. Data presentenced as % vehicle response ± SEM; ambulation, XAMB (a) or breaths per minute, BPM (b).
