Table 3.
Odds ratio (OR) of colorectal cancer in men and women by sex-specific quartiles of concentration of leptin, adiponectin, and sTNFR2 in the CLUE II cohort
| Case/Control | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | ||
| Men | |||||||
| Adiponectin | |||||||
| 1st Quartile | 33/22 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 14/22 | 0.46 | 0.19–1.09 | 0.49 | 0.19–1.27 | 0.48 | 0.19–1.24 |
| 3rd Quartile | 14/24 | 0.45 | 0.19–1.03 | 0.50 | 0.20–1.24 | 0.50 | 0.20–1.25 |
| 4th Quartile | 28/21 | 0.99 | 0.43–2.29 | 0.79 | 0.31–2.01 | 0.81 | 0.32–2.08 |
| Per 50th percentile* | 0.78 | 0.28–2.21 | 0.63 | 0.20–1.99 | 0.65 | 0.08–3.89 | |
| p-trend | 0.6 | 0.4 | 0.5 | ||||
| Leptin | |||||||
| 1st Quartile | 26/23 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 11/21 | 0.40 | 0.14–1.12 | 0.45 | 0.14–1.43 | 0.39 | 0.12–1.31 |
| 3rd Quartile | 31/23 | 1.19 | 0.52–2.75 | 1.50 | 0.60–3.76 | 1.25 | 0.46–3.40 |
| 4th Quartile | 21/22 | 0.81 | 0.34–1.90 | 0.88 | 0.34–2.25 | 0.59 | 0.16–2.12 |
| Per 50th percentile* | 1.18 | 0.25–5.65 | 1.48 | 0.26–8.34 | 0.98 | 0.09–10.04 | |
| p-trend | 0.8 | 0.7 | 0.9 | ||||
| sTNFR2 | |||||||
| 1st Quartile | 16/23 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 14/21 | 1.07 | 0.38–3.03 | 1.08 | 0.34–3.42 | 1.16 | 0.36–3.78 |
| 3rd Quartile | 19/24 | 1.40 | 0.51–3.85 | 1.21 | 0.40–3.66 | 1.34 | 0.43–4.16 |
| 4th Quartile | 40/21 | 3.06 | 1.19–7.88 | 3.14 | 1.11–8.86 | 3.46 | 1.19–10.06 |
| Per 50th percentile* | 1.37 | 1.08–1.73 | 1.38 | 1.07–1.78 | 1.41 | 1.08–1.83 | |
| p-trend | 0.01 | 0.01 | 0.01 | ||||
| Women | |||||||
| Adiponectin | |||||||
| 1st Quartile | 32/26 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 24/27 | 0.68 | 0.31–1.51 | 0.70 | 0.31–1.60 | 0.69 | 0.29–1.62 |
| 3rd Quartile | 35/25 | 1.02 | 0.51–2.02 | 1.02 | 0.49–2.13 | 1.01 | 0.47–2.14 |
| 4th Quartile | 13/26 | 0.34 | 0.13–0.88 | 0.34 | 0.12–0.94 | 0.33 | 0.12–0.95 |
| Per 50th percentile* | 0.14 | 0.01–2.09 | 0.14 | 0.01–2.71 | 0.14 | 0.01–2.85 | |
| p-trend | 0.2 | 0.2 | 0.2 | ||||
| p-interaction | 0.02 | 0.05 | 0.05 | ||||
| Leptin | |||||||
| 1st Quartile | 22/27 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 29/25 | 1.45 | 0.67–3.14 | 1.49 | 0.66–3.36 | 1.51 | 0.66–3.48 |
| 3rd Quartile | 31/26 | 1.44 | 0.69–3.02 | 1.14 | 0.50–2.59 | 1.17 | 0.48–2.85 |
| 4th Quartile | 22/26 | 1.05 | 0.48–2.26 | 0.98 | 0.42–2.29 | 1.02 | 0.38–2.76 |
| Per 50th percentile* | 1.27 | 0.03–54.07 | 0.60 | 0.01–40.36 | 0.75 | 0.01–110.74 | |
| p-trend | 0.9 | 0.8 | 0.9 | ||||
| p-interaction | 0.2 | 0.2 | 0.2 | ||||
| sTNFR2 | |||||||
| 1st Quartile | 24/27 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 26/25 | 1.18 | 0.54–2.57 | 1.13 | 0.50–2.56 | 1.13 | 0.50–2.59 |
| 3rd Quartile | 29/26 | 1.29 | 0.57–2.97 | 1.21 | 0.49–2.96 | 1.22 | 0.49–3.03 |
| 4th Quartile | 25/26 | 1.12 | 0.48–2.64 | 1.15 | 0.45–2.90 | 1.17 | 0.45–3.02 |
| Per 50th percentile* | 1.04 | 0.77–1.42 | 1.05 | 0.75–1.47 | 1.06 | 0.75–1.49 | |
| p-trend | 0.8 | 0.8 | 0.7 | ||||
| p-interaction | 0.2 | 0.2 | 0.2 | ||||
Model 1 – Matched model (matched on age, race, date of blood draw, and time since last meal)
Model 2 – Model 1 plus mutually adjusted for leptin, adiponectin, and sTNFR2
Model 3 – Model 2 plus further adjusted for BMI (continuous)
*
The 25th to 75th percentile delta is based on the biomarker concentration distribution for men and women combined
**
The 25th to 75th percentile delta is based on the biomarker concentration distribution separately in men and women