Table 5.
Odds ratio of adenoma in men and women by sex-specific quartiles of concentration of leptin, adiponectin, and sTNFR2 in CLUE II
| Case/Control | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | ||
| Men | |||||||
| Adiponectin | |||||||
| 1st Quartile | 14/16 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 15/17 | 1.02 | 0.36–2.88 | 1.11 | 0.38–3.23 | 1.11 | 0.38–3.22 |
| 3rd Quartile | 11/17 | 0.79 | 0.24–2.56 | 0.85 | 0.25–2.93 | 0.85 | 0.25–2.93 |
| 4th Quartile | 27/17 | 1.96 | 0.66–5.82 | 2.39 | 0.75–7.64 | 2.41 | 0.74–7.78 |
| Per 50th percentile* | 2.36 | 0.65–8.65 | 2.78 | 0.71–10.96 | 2.78 | 0.69–11.20 | |
| p-trend | 0.2 | 0.1 | 0.2 | ||||
| Leptin | |||||||
| 1st Quartile | 12/16 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 16/17 | 1.25 | 0.49–3.22 | 1.12 | 0.39–3.18 | 1.10 | 0.37–3.30 |
| 3rd Quartile | 23/17 | 1.84 | 0.68–4.97 | 2.09 | 0.72–6.05 | 2.03 | 0.61–6.77 |
| 4th Quartile | 16/17 | 1.26 | 0.46–3.51 | 1.44 | 0.46–4.45 | 1.39 | 0.37–5.25 |
| Per 50th percentile* | 2.09 | 0.23–18.55 | 3.26 | 0.30–35.79 | 2.82 | 0.16–48.54 | |
| p-trend | 0.5 | 0.3 | 0.5 | ||||
| sTNFR2 | |||||||
| 1st Quartile | 16/16 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 18/17 | 0.97 | 0.36–2.64 | 0.85 | 0.29–2.46 | 0.85 | 0.29–2.46 |
| 3rd Quartile | 21/18 | 1.12 | 0.41–3.07 | 0.78 | 0.26–2.40 | 0.78 | 0.26–2.39 |
| 4th Quartile | 12/16 | 0.69 | 0.21–2.27 | 0.53 | 0.14–1.98 | 0.53 | 0.14–1.98 |
| Per 50th percentile* | 0.91 | 0.60–1.37 | 0.81 | 0.51–1.27 | 0.80 | 0.51–1.27 | |
| p-trend | 0.6 | 0.4 | 0.4 | ||||
| Women | |||||||
| Adiponectin | |||||||
| 1st Quartile | 14/16 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 15/16 | 1.14 | 0.37–3.50 | 1.08 | 0.30–3.81 | 1.17 | 0.32–4.23 |
| 3rd Quartile | 24/16 | 1.66 | 0.64–4.30 | 1.62 | 0.55–4.77 | 1.80 | 0.59–5.54 |
| 4th Quartile | 11/16 | 0.71 | 0.24–2.13 | 0.57 | 0.16–1.99 | 0.61 | 0.17–2.17 |
| Per 50th percentile* | 1.00 | 0.05–22.09 | 0.58 | 0.02–18.92 | 0.69 | 0.02–23.91 | |
| p-trend | 0.9 | 0.8 | 0.8 | ||||
| p-interaction | 0.1 | 0.1 | 0.1 | ||||
| Leptin | |||||||
| 1st Quartile | 20/16 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 12/16 | 0.58 | 0.21–1.62 | 0.53 | 0.17–1.69 | 0.48 | 0.14–1.57 |
| 3rd Quartile | 18/16 | 0.87 | 0.31–2.40 | 0.74 | 0.22–2.48 | 0.64 | 0.18–2.26 |
| 4th Quartile | 14/16 | 0.66 | 0.22–1.94 | 0.49 | 0.13–1.84 | 0.34 | 0.07–1.68 |
| Per 50th percentile* | 0.17 | 0.00–130.66 | 0.03 | 0.00–89.99 | 0.00 | 0.00–65.56 | |
| p-trend | 0.6 | 0.4 | 0.8 | ||||
| p-interaction | 0.7 | 0.7 | 0.7 | ||||
| sTNFR2 | |||||||
| 1st Quartile | 13/16 | 1 | Ref | 1 | Ref | 1 | Ref |
| 2nd Quartile | 17/16 | 1.47 | 0.43–5.04 | 1.70 | 0.44–6.57 | 1.62 | 0.41–6.35 |
| 3rd Quartile | 15/16 | 1.33 | 0.39–4.55 | 1.82 | 0.42–7.88 | 1.87 | 0.43–8.15 |
| 4th Quartile | 19/16 | 1.59 | 0.52–4.84 | 2.03 | 0.53–7.75 | 2.00 | 0.52–7.65 |
| Per 50th percentile* | 1.10 | 0.84–1.44 | 1.17 | 0.84–1.63 | 1.17 | 0.84–1.63 | |
| p-trend | 0.5 | 0.4 | 0.3 | ||||
| p-interaction | 0.7 | 0.8 | 0.8 | ||||
Model 1 – Matched model (matched on age, race, date of blood draw, and time since last meal)
Model 2 – Model 1 plus mutually adjusted for leptin, adiponectin, and sTNFR2
Model 3 – Model 2 plus further adjusted for BMI (continuous)
*
The 25th to 75th percentile delta is based on the biomarker concentration distribution for men and women combined
**
The 25th to 75th percentile delta is based on the biomarker concentration distribution separately in men and women