Table 2.

PBPK Model Tumor Parameter Values and Definitions.

Parameter	Value	Units	Definition
QTU	1 × 10−4	L/min	Tumor blood flow [7]
LTU	4 × 10−6	L/min	Tumor lymph flow [7]
ClupTU	8.18 × 10−9	L/min	Initial tumor uptake clearance [14]
σTUV	0.734	-	Tumor vascular reflection coefficient [7]
σTUL	0.2	-	Lymph reflection coefficient [7]
ClTU	8.96 × 10−9	L/min	Initial clearance from endothelial space [14]
KDFcRn	7.5 × 10−7	M–1	FcRn-mAb KD [7]
CFcRn	1.64 × 10−5	M	Tumor FcRn concentration [14]
FR	0.715	-	Fraction of FcRn bound antibody recycled [7]
kgrowth	8.08 × 10−5	min–1	Tumor growth rate [7]
VITU	1.38 × 10−4	L	Initial Interstitial Volume [14]
VETU	1.25 × 10−6	L	Initial Endothelial Volume [14]
VVTU	1.75 × 10−5	L	Initial Vasculature Volume [14]
KDEGFR	1.5 × 10−10	M–1	Cetuximab-EGFR KD [4]
Kint	1.38 × 10−3	min–1	EGFR Internalization Rate [65,66]
ClTMD	Kint × VITU	L/min	Cetuximab Bound EGFR Clearance
CEGFR (NCI-N87)	1.14 × 10−7	M	EGFR Tumor Concentration [67,68,69]
CEGFR (Panc-1)	9.24 × 10−8	M	EGFR Tumor Concentration [70]
CEGFR (LS174T)	3.53 × 10−8	M	EGFR Tumor Concentration [67,68]