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ER stress sensor proteins and MAM proteins as therapeutic targets in HD. Inhibition of ERAD by mHtt toxic oligomers can induce ER stress. ER stress sensors (like IRE1, PERK) sense proteostasis imbalance activates unfolded protein response pathways. The a, b, c, d, e & f indicate possible points of therapeutic intervention either at the level of ER stress sensor or MAM proteins.
