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. 2022 Jan 6;23(2):589. doi: 10.3390/ijms23020589

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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BMP5 contributes to reduce migration and invasion abilities of tumor cells. (A) Low BMP5 expression is associated with poor survival outcomes of breast cancer patients. (B) Patients with stage 3 disease showed higher BMP5 levels than those of stage 2 patients. (C,D) Migration/invasion abilities were decreased by treatment of recombinant BMP5; however, the capabilities were enhanced following BMP5 downregulation. p values were calculated using ANOVA. * p < 0.05, ** p < 0.01, **** p < 0.0001.