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. 2022 Jan 13;23(2):859. doi: 10.3390/ijms23020859

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TNF and IL-17A dual blockade therapy affects bone remodeling in axial joints. (a) Representative micro-computed tomography (CT) image of the Caudal 3-Caudal 4 (Ca3-Ca4) vertebrae of HLA-B27/huβ2m transgenic rats who were treated five weeks with anti-TNF and anti-IL-17A (8C11 and B6-17, n = 4), anti-TNF (8C11, n = 5), anti-IL-17A (B6-17, n = 4), or vehicle control (n = 5). (b) Scoring of micro-CT images of Ca3-Ca4 vertebrae of age and gender matched non-diseased rats and the three treatment modalities compared to vehicle control. Compared to vehicle control, all three treatment modalities showed numerical, but non-significant, decreases for new bone proliferation and a significant decreases for roughness (anti-TNF, p = 0.019; anti-IL17A, p = 0.036; dual blockade, p = 0.004). The dual blockade therapy group showed the strongest decreases (−78% for new bone formation and −103% for roughness). *, p ≤ 0.05; **, p ≤ 0.01.

TNF and IL-17A dual blockade therapy affects bone remodeling in axial joints. (a) Representative micro-computed tomography (CT) image of the Caudal 3-Caudal 4 (Ca3-Ca4) vertebrae of HLA-B27/huβ2m transgenic rats who were treated five weeks with anti-TNF and anti-IL-17A (8C11 and B6-17, n = 4), anti-TNF (8C11, n = 5), anti-IL-17A (B6-17, n = 4), or vehicle control (n = 5). (b) Scoring of micro-CT images of Ca3-Ca4 vertebrae of age and gender matched non-diseased rats and the three treatment modalities compared to vehicle control. Compared to vehicle control, all three treatment modalities showed numerical, but non-significant, decreases for new bone proliferation and a significant decreases for roughness (anti-TNF, p = 0.019; anti-IL17A, p = 0.036; dual blockade, p = 0.004). The dual blockade therapy group showed the strongest decreases (−78% for new bone formation and −103% for roughness). *, p ≤ 0.05; **, p ≤ 0.01.