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. 2022 Jan 13;23(2):859. doi: 10.3390/ijms23020859

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TNF and IL-17A dual blockade therapy affects bone remodeling in peripheral joints. (a) Representative micro-CT image of the ankles of HLA-B27/huβ2m transgenic rats who were treated with anti-TNF and anti-IL-17A (8C11 and B6-17, n = 3–4), anti-TNF (8C11, n = 5), anti-IL-17A (B6-17, n = 4), or PBS (n = 5). (b) Scoring of micro-CT images of calcaneus and tarsal bones of age and gender matched non-diseased rats and the three treatment modalities compared to vehicle control. Numerical, but non-significant, decreases were seen for the dual and both single treatment groups compared to vehicle control for the assessed regions, reaching significance for anti-IL-17A (p = 0.031) treatment on tarsal bone loss. *, p ≤ 0.05.

TNF and IL-17A dual blockade therapy affects bone remodeling in peripheral joints. (a) Representative micro-CT image of the ankles of HLA-B27/huβ2m transgenic rats who were treated with anti-TNF and anti-IL-17A (8C11 and B6-17, n = 3–4), anti-TNF (8C11, n = 5), anti-IL-17A (B6-17, n = 4), or PBS (n = 5). (b) Scoring of micro-CT images of calcaneus and tarsal bones of age and gender matched non-diseased rats and the three treatment modalities compared to vehicle control. Numerical, but non-significant, decreases were seen for the dual and both single treatment groups compared to vehicle control for the assessed regions, reaching significance for anti-IL-17A (p = 0.031) treatment on tarsal bone loss. *, p ≤ 0.05.