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. 2022 Jan 6;23(2):627. doi: 10.3390/ijms23020627

Table 2.

IL-24 in inflammatory and autoimmune diseases.

Diseases Role
Psoriasis

  • high expression in skin lesion

  • promotes skin inflammation

  • activates keratinocytes
RA

  • high expression in inflamed joint

  • promotes mononuclear cell infiltration
IBD

  • highly expressed in inflamed mucosa

  • protects and maintains epithelial and mucosal integrity
MS and Uveitis

  • IL-24 deficiency leads to overactivation of Th17 cells and exacerbates both EAE and EAU
Liver inflammation

  • reduced expression in severe liver fibrosis

  • inhibits hepatic stellate cells and reduces liver inflammation and fibrosis