Figure 8.

H798P GT variant. (a) N_eq of the wild system (H798, color in black) and GT variant (P798, color in red). (b) ΔPB between the two systems. The mutated residue is indicated by a black line, and the residue with the strongest ΔPB by arrows. PB occurrence maps are shown around position 748 and 943 (c,f) for the wild-type and (d,e) for the variant. (g) Interactions of residue H798 (cyan) and (h) of residue P798 (light cyan); in orange, the residues interact in the same way in the wild-type and the variant; in violet, the new interacting residue. (i) Same representation for the residue L943 in the wild-type and (j) for the variant. Representation of the Calf-1 and Calf-2 domains according to the flexibility measured by values of N_eq for (k) wild-type and (l) for the variant, moving from the least flexible (thin line, blue) to the most mobile (thick line, red). The most mobile parts representing high values of N_eq are circled in red.