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. 2022 Jan 6;23(2):604. doi: 10.3390/ijms23020604

Figure 2.

Figure 2

Anti-angiogenic and direct anti-cancer effects mediated by CD47. (A) TSP-1 inhibits angiogenesis via binding to CD36 and CD47. However, TSP-1 mediated inhibition of angiogenesis by binding to CD36 is also regulated via CD47. In addition, CD47 directly interacts with vascular endothelial growth factor receptor-2 (VEGFR-2) on endothelial cells. By binding to CD47, this interaction is abrogated by TSP-1, whereby angiogenesis is inhibited. Further, TSP-1 can directly bind to VEGF, thereby preventing its interaction with VEGFR-2. (B) Crosslinking of CD47 by antibodies or TSP-1 can lead to caspase-independent cancer cell death. Image created with BioRender.com (accessed on 14 January 2021).