Table 1.

TSP-1 concentration effects.

TSP-1 Concentration	Ligand	Signaling Pathway/Proteins	Effect
10–100 pM	CD47	NO/cGMP/cGK	Increased endothelial cell adhesion [125,126,131,135]
		eNOS/NO/sGC	Anti-angiogenic effect/inhibits NO production [127,131]
100–150 pM	CD47	VEFGR2 direct binding	Anti-angiogenic effect [125,138]
1–10 nM	CD36	NO/cGMP/cGK Src kinasesFyn/p38 phosphorylation	Inhibits NO production Anti-angiogenic effect [126] Endothelial cell apoptosis [139]