Figure 2.

SPON1-TRIM29 expression blunts chemotherapy drug sensitivity in ovarian cancer cells. (a–c) SPON1-TRIM29- and vector-transfected A2780 cells were seeded in 96 well-plate on day 0 and treated with either cisplatin (a), paclitaxel (b), or olaparib (c) at the indicated concentrations on day 1. Vehicle treatment corresponding to each drug treatment is indicated as (−). The medium was removed at the indicated time points and DNA assay was performed to estimate cell proliferation. Data are presented as means ± SD (n = 3). * p < 0.05, ** p < 0.01, two-way ANOVA.