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. 2022 Jan 6;23(2):596. doi: 10.3390/ijms23020596

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of obesity, insulin resistance, and type 2 diabetes on basal and postprandial plasma insulin clearance rate. Left panel: Whole-body plasma insulin clearance rate during basal conditions and for three hours after glucose ingestion. Right panel: Plasma insulin clearance rate in relationship to insulin delivery to tissues during basal conditions and during the early postprandial period. Adapted from references [3,8,83]. Abbreviations: ICR, insulin clearance rate; IS, insulin sensitive; IR, insulin resistant; Ob, obese; T2D, type 2 diabetes.