Table 1.

MIC of BTZ043 and selamectin against a set of M. tuberculosis mutants resistant to a variety of anti-TB compounds. Isoniazid was included as internal control of activity. The “references” column indicates the first reports for the strains used in this study. INH, isoniazid; STR, streptomycin; RIF, rifampicin; EMB, ethambutol; PYR, pyridomycin; ETH, ethionamide; CAP, capreomycin; BTZ, benzothiazinones; nd: not determined.

M. tuberculosis Strain	Strain Resistance Profile	MIC INH (µg/mL)	MIC SEL (µg/mL)	MIC BTZ043 (ng/mL)	Reference
H37Rv		0.025	4	1
H37Rv-pSODIT				1
53.3 (Rv2466c, W28S)	TP053	0.025	2–4	nd
53.8 (Rv0579, L240V)	TP053	0.025	2–4	nd	[23]
NTB1 (DprE1 C387S)	BTZ	0.025	2	>1000	[22]
NTB9 (DprE1 C387G	BTZ	0.025	2	1000	[22]
H37Rv-pSODIT:dprE1	BTZ	0.025	4	1000
DR1 (mmpL3, V681I)	1,5-diarylpyrroles	0.025	2–4	nd	[24]
Ty1 (Rv3405c, c190t)	Ty38c	0.025	2–4	nd	[25]
88.1 (coaA, Q207R)	Thiophenecarboxamide derivatives	0.025	2–4	nd	[26]
88.7 (pyrG, V186G)	Thiophenecarboxamide derivatives	0.025	2–4	nd	[26]
81.10 (ethA, D1109-37)	Thiophenecarboxamide derivatives	0.025	4–8	nd	[26]
IC1	STR, INH, RIF, EMB	>0.2	4–8	nd	[27]
IC2	STR, INH, RIF, EMB, PYR, ETH, CAP	>0.2	4–8	nd	[27]