Figure 7. Tomogram depicting lateral links containing PCDH15 in small stereocilia.

(A) Annotation of tomogram showing developing stereocilia including PCDH15-containing ‘lateral links.’ The inset at the bottom right shows a projection of the tomogram. (B, C) Close-up of putative CDH23 molecules clustering together into single strand. (D) Close-up of a putative CDH23 molecule with distinct bend halfway between N- and C-terminal end.

Figure 7—video 1. Tomogram of stereocilia connected by tens of PCDH15-containing complexes.

Download video file ^{(23.3MB, mp4)}

Noteworthy complexes that include apparent interaction between putative CDH23 dimers, as well as bends in the putative CDH23 dimer are highlighted. Also depicted in Figure 7.